Public Health
INSTITUTE OF SEROLOGY KOLKATA
1. Introduction: Institute of Serology Kolkata was established on 17th September, 1912 and is now a subordinate office of Directorate General of Health Services, under the Ministry of Health & F.W. of India. Current activities of the Institute are as under;
i. Production of various quality diagnostic reagents like Antigen, species specific Antisera, Anti H Lectin etc. and supply to the Government and Non-Government Institutions like Forensic Science Laboratories and Hospitals all over the country.
ii. Forensic Serology for determination of origin of species of different biological exhibits and undertake blood group serology in case the species origin is human.
iii. Institute also serve as National Referral Laboratory for identification of Measles and Rubella
iv. Training of Laboratory Technicians in various fields of Serology and Sexually Transmitted Diseases and imparting training in Forensic Serology to post graduate students of Forensic Medicine.
v. Referral laboratory/Centre for A, B, O Blood grouping & Rh typing, V. D. Serology, Isolation of Polio Virus.
2. Administrative Activities
2.1. Staff Strength:
• Total Sanctioned Strength of staff -93
• Staff in position at IOSK -60
• Vacant positions at IOSK -36
• % vacant position at IOSK -35.48% Consolidated status of the staff is given in the table No.1.
Table No. 1
Group-wise staff position of CRI Kasauli
| S. No. |
Staff |
sanctioned strength |
Staff in-position |
Vacant positions |
% Vacancies |
|
1
|
Group-A
|
9
|
6
|
3
|
33.33
|
|
2
|
Group-B (Gaz)
|
2
|
0
|
2
|
100.00
|
|
3
|
Group-B(NG)
|
5
|
1
|
4
|
80.00
|
|
4
|
Group-C (Technical)
|
53
|
32
|
21
|
39.62
|
| |
Group C (Ministerial)
|
24
|
21
|
3
|
12.50
|
| |
Total
|
93
|
60
|
33
|
35.48
|
Detailed staff position is given in Annexure 1
2.2Budget Performance:
- BE 2015-16 is Rs. 630.00 lakh (Plan Rev Rs. 55.00 lakh and Non-plan Rs. 575.00 lakh)
- RE 2015-16 Rs. xx lakh (Plan Rev Rs. 7.04 lakh and Non-plan Rs. 284.49 lakh)
- FE 2015-16 Rs. xx lakh (Plan Rev Rs. 45.50 lakh and Non-plan Rs. 594.39 lakh).
- Expenditure 2015-16 xx
- % Utilization against FE is xx (Plan Rev 7.82% and Non-plan 50.45%).
- BE 2015-16 is Rs. 634.00 lakh (Plan Rs. 34.00 lakh and non-plan Rs. 600.00 lakh)
Consolidated allocation & utilization of budget 2013-14 is given in table No. 2.
Table No. 2
Budget Provisions
(Rs. in Lakh)
| S. No |
Year |
Plan |
Non-Plan |
Total |
|
1
|
BE 2015-16
|
55.00
|
575.00
|
630.00
|
|
2
|
RE 2015-16
|
55.00
|
575.00
|
630.00
|
|
3
|
FE 2015-16
|
|
|
0
|
|
4
|
Expenditure 2015-16
|
|
|
0
|
|
5
|
% Expenditure against FE
|
|
|
0
|
|
6
|
BE 2016-17
|
34.00
|
600.00
|
634.00
|
3. Technical support Services:
3.1. Medico-legal Section:
| S. No |
Samples |
No. of fresh samples received |
No. of samples analyzed |
No. of samples reported
|
|
I
|
Forensic Cases)
|
1036
|
|
|
|
ii
|
Forensic Exhibits
|
4511
|
|
|
|
iii
|
Items for Species determination
|
4984
|
|
|
|
iv
|
Items for Blood Grouping
|
1111
|
|
|
| |
Total
|
|
|
|
3.2. VD Serology
| S. No |
Samples |
No. samples Received |
No. Of samples found Positive |
No. of samples for which Report Given |
|
i
|
Antenatal cases
|
-
|
-
|
-
|
|
ii
|
STD clinic samples
|
2537
|
90
|
2537
|
|
iii
|
Ref. Lab. Pool
|
-
|
-
|
-
|
|
|
Total
|
2537
|
90
|
2537
|
3.3. STD/Bacteriology Section
| S. No |
Samples |
No. samples Received |
No. Samples Positive test 1 |
No. Of samples positive test 2 |
|
i
|
Syphilis
|
2637
|
90 VDRL
|
137 TPHA
|
|
ii
|
Candida
|
1992
|
206 Gram stain
|
252 Culture
|
|
iii
|
Gonorrhea
|
1839
|
06 Direct Smear
|
00 Culture
|
|
iv
|
B. Veginosis
|
1992
|
238 KOH
|
|
|
v
|
Hepatitis B
|
2329
|
20 Elisa
|
29 Immu Rech
|
|
vi
|
Hepatitis C
|
92
|
0
|
2 imm rech
|
|
vii
|
PAP Smear
|
1755
|
0
|
0
|
|
viii
|
HSV – 2
|
366
|
48 (ELISA
|
|
|
ix
|
Trichomonas Vaginalis
|
1992
|
415 Wet Mount
|
496 Culture
|
|
x
|
C. Trachomatis
|
184
|
59 ELISA
|
|
|
xi
|
Non Herpetic Syndrome
|
124
|
3 GiMSA
|
|
|
xii
|
Herpetic Syndrome
|
68
|
13 GIMSA
|
|
|
xiii
|
CMV
|
00
|
00 ELISA
|
|
|
|
Total
|
|
|
|
Production Division
3.4. Antigen and Antibody Production Division (Production, Demand and supplies)
Quantity in Number of Ampoules/vials
| S. No |
Vaccine / Anti-sera |
Installed Capacity |
Quantity manufactured |
Demand received |
Quantity supplied |
|
i
|
VDRL Antigen
|
|
3640 amp
|
3340 amp
|
3340 amp
|
|
ii
|
Antisera against animal species
|
|
4890 ml
|
2279 ml
|
4270 ml
|
|
|
Total
|
|
|
|
|
3.5. BGRC Section
Quantity in numbers of Ampoules/Vials
| S. No |
Vaccine / Anti-sera |
Installed Capacity |
Quantity manufactured |
Demand received |
Quantity supplied |
|
|
i
|
Anti-H Lectin
|
|
2600 ml
|
|
|
|
ii
|
A-1 Lectin
|
|
-
|
-
|
-
|
|
iii
|
Blood Grouping antigen
|
|
537
|
|
|
|
iv
|
Anti D (Rh factor)
|
|
19
|
|
|
|
|
Total
|
|
|
|
|
4. Quality Control Division
| S. No |
Lots |
No. of Lots Received No. of Lots Tested |
No. of Lots Cleared |
No. of Lots Rejected |
|
i
|
Anti-H Lectin
|
72
|
72
|
72
|
0
|
|
ii
|
Species Anti-serum
|
18
|
18
|
18
|
0
|
|
iii
|
VDRL Antigen
|
05
|
05
|
05
|
0
|
|
|
Total
|
95
|
95
|
95
|
0
|
5. Surveillance section
5.1. National Polio Laboratory
| S. No |
Samples |
Numbers |
|
i
|
Total cases/samples received
|
13024
|
|
ii
|
NPEV positive
|
1076
|
|
iii
|
L20 B Positive
|
127
|
|
iv
|
Environment Sample received
|
208
|
|
v
|
L20 B Positive
|
226
|
5.2. Measles Laboratory
5.2.1. Measles samples
| S. No |
Samples |
Numbers |
|
i
|
Total cases/samples received
|
972
|
|
ii
|
No. of samples tested
|
972
|
|
iii
|
No. of samples found Positive
|
481
|
|
iv
|
No. of samples found Negative
|
485
|
|
v
|
No. of samples found equivocal
|
00
|
5.2.2. Rubella samples
| S. No |
Samples |
Numbers |
|
i
|
Total cases/samples received
|
432
|
|
ii
|
No. of samples tested
|
432
|
|
iii
|
No. of samples found Positive
|
155
|
|
iv
|
No. of samples found Negative
|
277
|
|
v
|
No. of samples found equivocal
|
00
|
BCG VL GUINDY – BRIEF ON ACTIVITIES
1.Introduction:
1.1. Organization
BCGVL Guindy was established in 1948 and currently is a sub-ordinate office of the Directorate General of Health Services (DGHS) under the Ministry of Health and Family Welfare of the Government of India, situated at Guindy, Chennai (Tamilnadu) near King Institute of Preventive Medicine. The institute has a huge complex, which is divided in five major sub-sections i.e. Establishment, Production Division, Quality Control Division, Animal House and Warehousing & Marketing. The other major facilities are Containerization, sterilization, Physical inspection.
1.2. Functions:
The major functions of the institute are production of BCG Vaccine (10 doses) for control of childhood Tuberculosis and supply to Expanded Programme of Immunization (EPI). Institute also manufactures therapeutic BCG Vaccine for management of bladder cancer.
2. Staff Strength
- sanctioned strength -113
- Staff in-position -95
- Requirement as cGMP -151
- Existing staff suitable -94
- New psts to be created -57
3. Budget Provisions:
- Budget Estimates 2015-16 -Rs. 2315.00 lakh
- RE (2015-16) proposed -Rs. 1684.00 lakh
- FE 2015-16 -Rs. 1465.00 lakh • Actual expenditure 2015-16 -Rs. 1384.85 lakh
- BE (2016-17) proposed - Rs. 2255.00lakh
4. Physical Performance of BCG
- Installed capacity for production of BCG vaccine of 800 lakh doses per annum.
- The Institute was meeting 100% of demand of BCG vaccines in the country, since 2002-03.
- However, after the suspension of the manufacturing license in Jan., 2008, the production and supply of the BCG Vaccine from the institute was stopped.
5. Up-gradation of BCG vaccine manufacturing facility:
- MOH&FW has taken a decision in a meeting under the Chairmanship of Secretary (H) on 1.3.2011, wherein it was decided that the BCGVL will be revived and a new cGMP compliant BCG vaccine manufacturing facility will be created at the exiting site.
- SFC was approved for creation of new facility for manufacturing of BCG vaccine and for renovation of Allied facilities at BCGVL.
- Ms. HLL was engaged for up-gradation of BCG vaccine manufacturing facility at BCGVL Chennai and to make it cGMP compliant with a cost of Rs. 64.72 Crores.
Status of completion of new facility as on date;
• Construction & Civil Works -Completed
• Purchase of equipments -Completed
• Installation Qualification -Completed
• Operation Qualification -Completed
• Validation -Completed
• DCG(I) Inspection -Completed
• Trial Batches -Planned from May 2016
• Consistency Batches -Planned from Oct 2016
6. Release of Funds to M/s HLL:
The status of Funds approved under the project and released to M/s HLL as on date are as under;
Total Funds approved as per SFC Rs. 64.72 Crore
Funds released till March 2015 Rs. 57.78 Crore
Balancefunds to released Rs. 6.94 Cro
BRIEF ON CENTRAL RESEARCH INSTITUTE KASAULI
1. Introduction:
1.1. Origin & Concept:
Central Research Institute was established on 3rd May, 1905 as Pasteur Institute for North India. It is a subordinate office of Directorate general of Health Services, under the Ministry of Health & F.W. of India. Since its inception the institute has developed into a premier institute in research and production of a number immunobiologicals.
1.2. Estate & Physical Infrastructure:
Land Area: Estate of CRI Kasauli consists of 67 Acres of land in four pieces situated within a radius of 1.5. Kms. The reference areas are: (i) Manufacturing wing, (ii) R&D wing, (iii) Drum-bar Estate and (iv) Belvedere Estate. CRI Kasauli has residential accommodation that houses about350 employees. The institute has a huge complex which divided in seven sub-sections i.e. Establishment, Academic, Auxiliary Facilities, Production Division, Quality Control Division, Animal House and Research & Surveillance Division.
1.3. Mandate
Central Research Institute is engaged in
- Large scale production of Bacterial and Viral Vaccines & Sera.
- Research and Development in the field of immunology and vaccinology.
- Teaching and training.
- Quality Control of vaccine and sera
2. Staff Strength:
- Total sanctioned staff strength -725
- Staff in-position -460
- Vacant positions -183
- Lapsed posts -82
3.Budget Performance:
Budget performance (2015-16):
- BE allocated is Rs. 5400.00 lakh
- RE propose (2015-16) is Rs. 5376.13 Lakh
- FE (2015-16) is Rs. 4220.27 Lakh
- Budget utilization as on 31.3.2016 is Rs. 3890.83 lakh
- BE(2016-17) Proposed is Rs. 7102.81 lakh
4.Technical Performance (2015-16):
Production and supplies of vaccine
- Manufacturing in existing facilities has been started
- Production in respect of DPT and TT is 41.16 lakh (16.14%) and 69.33% respectively.
- Supply against demand in respect of DPT and TT is 69.33% and 33.66% respectively.
Details of Batches started, quantity manufactured, and demand received and quantity released is given in table 3.
Table No. 3
Production, demand and supply of the vaccine and anti-sera:
(Quantity in lakh of doses)
|
S. No
|
Vaccines & antisera
|
Installed Capacity
|
Production
|
% Produced
|
Demand
|
Supplies
|
% Supplied
|
|
1
|
DPT
|
255
|
41.16
|
16.14%
|
75.00
|
52.00
|
69.33%
|
|
2
|
DT
|
200
|
0
|
|
|
|
|
|
3
|
TT
|
300
|
35.19
|
11.735
|
101.71
|
34.71
|
33.66
|
|
4.1
|
YFV (CRIK)
|
0.35
|
|
0.00
|
|
|
|
|
4.2
|
YFV (IMPORT)
|
|
0.93
|
|
0.52
|
0.41
|
78.73%
|
|
5
|
ARS
|
2.5
|
0.22
|
8.96%
|
0.53
|
0.18
|
34.66
|
|
6
|
ASVS
|
3.00
|
0.015
|
5.06%
|
0.069
|
0.014
|
20.59%
|
|
7
|
DATS
|
0.80
|
0.051
|
6.4%
|
0.081
|
0.042
|
51.92%
|
|
8
|
NHS
|
0.004
|
0
|
0.00
|
0.0025
|
0.0001
|
4.44%
|
|
9
|
DR
|
2.75
|
0.14
|
5.06%
|
0.27
|
0.12
|
45.07%
|
Qty. in lakh of vials
5 . Surveillance activities
Samples received for;
- Salmonella & E.coli -NIL
- Rabies Research -NIL
- Influenza Surveillance -105
- Polio surveillance -4094
6. Research & Development
- Number of projects in the beginning -Nil
- Number new projects started -05
- Number of projects Completed -Nil
- Number of projects continuing at end -05
7. Medical care facilities provided;
- OPD care -7194
- Indoor Admissions -123
- Lab Investigations -6366
- Physiotherapy -617
- Referral -37
- YF Vaccination -2222
- Medical Check up -282
- Dog-bite cases -1034
- ECG -319
- Nebulization -231
- Others -5209
1. Animal House
- Equines -68
- Sheep -14
- Guiea Pigs -580
- Mice -5250
2. Academic Activities
- PG Courses -11
- Project Work -03
- Practical Training -34